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In vivo Endomicroscopy

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In vivo Endomicroscopy

Imaging in live experimental animals at cellular resolution opens up new frontiers for the study of biological processes and for the development of medical treatments. From imaging the effects of stem cells on the intracellular environment, to identifying tumors hidden under epithelial tissues, endomicrocopy provides a unique combination of resolution, depth, and non-invasiveness which allows extended microscopy of cells and tissues in their natural biological environment.

Imaging in live experimental animals at cellular resolution opens up new frontiers for the study of biological processes and for the development of medical treatments. From imaging the effects of stem cells on the intracellular environment, to identifying tumors hidden under epithelial tissues, endomicrocopy provides a unique combination of resolution, depth, and non-invasiveness which allows extended microscopy of cells and tissues in their natural biological environment.

* Selected papers :

1.“Micro-endoscopic In Vivo Monitoring in the Blood and Lymphatic Vessels of the Oral Cavity after Radiation Therapy,” International Journal of Medical Sciences (IJMS),  16(11): 1525-1533, Oct. 2019.
2.“In vivo Fluorescence Micro-endoscopic Monitoring of Stent-induced Fibroblast Cell Proliferation in an Esophageal Mouse Model,” Journal of Vascular and Interventional Radiology (JVIR), Vol 29(12), 1756-1763, Dec., 2018.
3.“In vivo imaging of Lgr5-positive cell populations using confocal laser endomicroscopy during early colon tumorigenesis,” Endoscopy, Vol. 46, No.12, pp. 1110-1115, Dec. 2014.
4.“350-um side-view optical probe for imaging the murine brain in vivo from the cortex to the hypothalamus,” Journal of Biomedical optics, Vol. 18, No. 5, 050502, May 2013.
5.“Optical fine-needle imaging biopsy of the brain,” Biomedical Optics Express, Vol.4, No.12, pp. 2846-2854, Dec. 2013.
6.“Fabrication and operation of GRIN probes for in vivo fluorescence cellular imaging of internal organs in small animals,” Nature Protocols, Vol.7, No.8, pp.1456-1469, Aug. 2012. (Featured as the Journal Cover)
Cover article of
Nature Protocols

* Selected papers :

1.“Micro-endoscopic In Vivo Monitoring in the Blood and Lymphatic Vessels of the Oral Cavity after Radiation Therapy,” International Journal of Medical Sciences (IJMS),  16(11): 1525-1533, Oct. 2019.
2.“In vivo Fluorescence Micro-endoscopic Monitoring of Stent-induced Fibroblast Cell Proliferation in an Esophageal Mouse Model,” Journal of Vascular and Interventional Radiology (JVIR), Vol 29(12), 1756-1763, Dec., 2018.
3.“In vivo imaging of Lgr5-positive cell populations using confocal laser endomicroscopy during early colon tumorigenesis,” Endoscopy, Vol. 46, No.12, pp. 1110-1115, Dec. 2014.
4.“350-um side-view optical probe for imaging the murine brain in vivo from the cortex to the hypothalamus,” Journal of Biomedical optics, Vol. 18, No. 5, 050502, May 2013.
5.“Optical fine-needle imaging biopsy of the brain,” Biomedical Optics Express, Vol.4, No.12, pp. 2846-2854, Dec. 2013.
6.“Fabrication and operation of GRIN probes for in vivo fluorescence cellular imaging of internal organs in small animals,” Nature Protocols, Vol.7, No.8, pp.1456-1469, Aug. 2012. (Featured as the Journal Cover)

Cover article of
Nature Protocols

1_In-vivo-endomicroscopy_3